Individuals with opioid-related disorders face a variety of risks, including potential overdose, which can be fatal. Comorbid mental health conditions, such as anxiety and depression, significantly augment the risk of substance use and complicate treatment. Social factors, such as unstable housing, lack of support systems, and socioeconomic challenges, further exacerbate these risks. Additionally, ongoing opioid use can lead to physical health issues like respiratory problems, liver disease, and infectious complications from intravenous drug use.