Pulmonary heart disease, also known as cor pulmonale, arises primarily from prolonged high blood pressure in the pulmonary arteries, commonly seen in conditions such as chronic obstructive pulmonary disease (COPD), interstitial lung disease, and pulmonary hypertension. Other contributing factors include chronic thromboembolic disease, sleep apnea, and certain congenital heart defects. These conditions lead to strain on the right side of the heart, ultimately resulting in right ventricular enlargement and dysfunction over time.